International Journal of Nutrition, Pharmacology, Neurological Diseases

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 6  |  Issue : 3  |  Page : 101--110

Efficacy of Vitamin E supplementation in patients with alcoholic liver disease: An open-label, prospective, randomized comparative study


Bhanu Prakash Kolasani, Prasanand Sasidharan, Adithiya Kumar 
 Department of Pharmacology, Vinayaka Missions Medical College and Hospital, Karaikal, Puducherry, India

Correspondence Address:
Dr. Bhanu Prakash Kolasani
Department of Pharmacology, Vinayaka Missions Medical College and Hospital, Kottucherry, Karaikal - 609 609,
India

Background: The evidence that oxidative stress is involved in the pathogenesis of ALD and Vitamin E deficiency being well documented in patients of ALD, an antioxidant like Vitamin E could likely be beneficial in patients with ALD. Methods: This is a prospective, open labeled, randomized comparative study of eight weeks duration, involving a total of 30 adult patients diagnosed with ALD who were randomized into two groups of 15 each and were designated as group A who received standard treatment and group B who received vitamin E along with standard treatment. Biochemical parameters like Liver Function Tests, De Ritis Ratio, Hb and TLC; prognostic parameters like Child Pugh Score and Model for End-Stage Liver Disease score were recorded before and after the treatment period in each group and compared. Results: In group A, the change observed in total protein and child pugh score were significant (P < 0.05) whereas that seen in PT was highly significant (P < 0.001). In group B, the changes observed in total protein, A:G ratio, bilirubin, PT, MELD score, Hb and TLC were significant (P < 0.05) whereas those seen in albumin, PT-INR, Child Pugh Score were highly significant (P < 0.001). When the differences observed in various parameters in Group A were compared with those seen in Group B, the changes in albumin, globulin and A:G ratio observed in Group B were statistically significant compared to their respective changes observed in Group A. Conclusion: These findings suggest that Vitamin E given in adequate dose will be a useful addition for treating alcoholic liver disease, although larger studies involving more number of patients should be done.


How to cite this article:
Kolasani BP, Sasidharan P, Kumar A. Efficacy of Vitamin E supplementation in patients with alcoholic liver disease: An open-label, prospective, randomized comparative study.Int J Nutr Pharmacol Neurol Dis 2016;6:101-110


How to cite this URL:
Kolasani BP, Sasidharan P, Kumar A. Efficacy of Vitamin E supplementation in patients with alcoholic liver disease: An open-label, prospective, randomized comparative study. Int J Nutr Pharmacol Neurol Dis [serial online] 2016 [cited 2021 Jan 27 ];6:101-110
Available from: https://www.ijnpnd.com/article.asp?issn=2231-0738;year=2016;volume=6;issue=3;spage=101;epage=110;aulast=Kolasani;type=0