International Journal of Nutrition, Pharmacology, Neurological Diseases

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 4  |  Issue : 5  |  Page : 17--22

Effects on chrysin on lipid and xenobiotic metabolizing enzymes in l-NAME-induced hypertension


Ramanathan Veerappan1, Thekkumalai Malarvili1, Govindaraju Archunan2 
1 Department of Biochemistry, Rajah Serfoji Government College, Thanjavur, India
2 Department of Animal Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

Correspondence Address:
Thekkumalai Malarvili
Department of Biochemistry, Rajah Serfoji Government College, Thanjavur - 613 001, Tamil Nadu
India

Objective: Nω-nitro-l-arginine methyl ester (l-NAME) is a non-specific nitric oxide (NO) synthase inhibitor, commonly used for the induction of NO-deficient hypertension. Hypertension is a significant risk factor in cardiovascular complications. Materials and Methods: This study was undertaken to investigate the effects of chrysin on lipid metabolizing enzymes, xenobiotic metabolizing enzymes, and microalbuminuria and N-acetyl-β-d-glucosaminidase (NAG) in urine in l-NAME-induced hypertensive rats. Hypertension was induced in adult male Wistar rats weighing 180-220 g by oral administration of l-NAME (40 mg/kg BW) in drinking water for 4 weeks. Rats were treated with chrysin (25 mg/kg BW) for 4 weeks. Results: The activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase increased significantly in the liver and kidney, whereas the activities of lipoprotein lipase and lecithin cholesterol acyl transferase decreased significantly in the plasma of hypertensive rats. Conclusions: The xenobiotic phase I enzymes, microalbuminuria, and NAG significantly increased, whereas xenobiotic phase II enzymes decreased in l-NAME-treated rats. Oral administration of chrysin reduced hyperlipidemia-related risk of hypertension.


How to cite this article:
Veerappan R, Malarvili T, Archunan G. Effects on chrysin on lipid and xenobiotic metabolizing enzymes in l-NAME-induced hypertension.Int J Nutr Pharmacol Neurol Dis 2014;4:17-22


How to cite this URL:
Veerappan R, Malarvili T, Archunan G. Effects on chrysin on lipid and xenobiotic metabolizing enzymes in l-NAME-induced hypertension. Int J Nutr Pharmacol Neurol Dis [serial online] 2014 [cited 2021 Jun 21 ];4:17-22
Available from: https://www.ijnpnd.com/article.asp?issn=2231-0738;year=2014;volume=4;issue=5;spage=17;epage=22;aulast=Veerappan;type=0