International Journal of Nutrition, Pharmacology, Neurological Diseases

: 2014  |  Volume : 4  |  Issue : 1  |  Page : 11--22

Clinical significance of probiotics in human

Diksha Jain, Hotam Singh Chaudhary 
 Department of Biotechnology, Madhav Institute of Technology and Science, Gwalior, Madhya Pradesh, India

Correspondence Address:
Hotam Singh Chaudhary
Department of Biotechnology, Madhav Institute of Technology and Science, Gwalior- 474 005, Madhya Pradesh

This review gives a glimpse of probiotic role in human life and how it affects the individual. Probiotics have been studied as an alternative to antibiotic therapy. The term DQprobioticsDQ comes from the Greek word DQpro biosDQ meaning DQfor lifeDQ opposed to DQantibiotics,DQ which means DQagainst life.DQ As the research is progressing, new approaches to treat diseases are being developed such as prebiotics and synbiotics. Probiotics work in our body through various modes of action, namely, production of inhibitory substances, stimulation of immunity, affecting host gene expression, blocking of adhesion sites, competition for nutrients, and degradation of toxin receptors. The various criteria employed to select strains for probiotics are acid-bile stability, adhesion stability, antimicrobial activity, viability and stability during processing and storage. Research has proved the therapeutic effects of probiotics in diseases such as diarrhea, rotavirus diarrhea, irritable bowel syndrome, Helicobacter pylori infection, hepatic encephalopathy, celiac disease, and hyperoxaluria. Probiotics have prophylactic effects in diseases such as pouchitis and ulcerative colitis that come under inflammatory bowel disease, antibiotic-induced diarrhea, necrotizing enterocolitis, ventilator-associated pneumonia, dental decay, periodontal infection, halitosis, constipation, gastrointestinal infections, and colon cancer. Probiotics also help in xenobiotic metabolism, lactose intolerance, cholesterol reduction, sucrase-isomaltase deficiency, stress, and hypertension. Further research is needed to prove the efficacy of probiotics in case of radiation-induced diarrhea, HIV/AIDS diarrhea, CrohnSQs disease, nonalcoholic fatty liver disease, and allergy.

How to cite this article:
Jain D, Chaudhary HS. Clinical significance of probiotics in human.Int J Nutr Pharmacol Neurol Dis 2014;4:11-22

How to cite this URL:
Jain D, Chaudhary HS. Clinical significance of probiotics in human. Int J Nutr Pharmacol Neurol Dis [serial online] 2014 [cited 2021 Jan 15 ];4:11-22
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