ORIGINAL ARTICLE
Year : 2013 | Volume
: 3 | Issue : 2 | Page : 114--120
Effect of Vimliv on lipid profile and histopathology in ethanol-induced hepatotoxicity in albino Wistar rats
Nagamani Samundeeswari, Murugan Rajadurai, Palanisamy Ganapathy, Sukumaran Rexlin Shairibha
Department of Biochemistry, Muthayammal College of Arts and Science, Rasipuram, Namakkal Dist., Tamil Nadu, India
Correspondence Address:
Murugan Rajadurai
Department of Biochemistry, Muthayammal College of Arts and Science, Rasipuram - 637 408, Namakkal Dist., Tamil Nadu
India
Background: Liver disease is considered to be a serious health problem, as the liver is an important organ for the detoxification and deposition of endogenous and exogenous substances. Objective: The present study is carried out to investigate the effect of Vimliv in ethanol-induced hepatotoxicity. Materials and Methods: Ethanol (3 g/kg) was dissolved in water and injected intragastrically, for a period of 35 days. Vimliv was dissolved in carboxy methyl cellulose and administered to rats at doses of 25 and 50 mg/kg for a period of 35 days as coadministration. Results: Administration of Vimliv resulted in significant reduction of blood glucose, serum urea, creatinine, lipid profile and increase in albumin. Administration of Vimliv also shows better pathological effects on liver and kidney. Conclusion: Therefore, this study suggests that Vimliv has the hepatoprotective effect and consequently may alleviate liver and renal damage associated with ethanol-induced hepatotoxicity in rats.
How to cite this article:
Samundeeswari N, Rajadurai M, Ganapathy P, Shairibha SR. Effect of Vimliv on lipid profile and histopathology in ethanol-induced hepatotoxicity in albino Wistar rats.Int J Nutr Pharmacol Neurol Dis 2013;3:114-120
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How to cite this URL:
Samundeeswari N, Rajadurai M, Ganapathy P, Shairibha SR. Effect of Vimliv on lipid profile and histopathology in ethanol-induced hepatotoxicity in albino Wistar rats. Int J Nutr Pharmacol Neurol Dis [serial online] 2013 [cited 2022 Jul 4 ];3:114-120
Available from: https://www.ijnpnd.com/article.asp?issn=2231-0738;year=2013;volume=3;issue=2;spage=114;epage=120;aulast=Samundeeswari;type=0 |
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