International Journal of Nutrition, Pharmacology, Neurological Diseases

CASE REPORT
Year
: 2013  |  Volume : 3  |  Issue : 1  |  Page : 70--72

Acute reversible Parkinsonism following accidental exposure to organophosphate insecticide


A. S. Praveen Kumar, D. K. S. Subrahmanyam 
 Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India

Correspondence Address:
A. S. Praveen Kumar
Department of Medicine, JIPMER, Pondicherry
India

Organophosphate insecticide (OPI) poisoning is one of the most common poisonings seen in rural south India. OPIs act by inhibiting acetylcholine esterase enzyme activity and thereby increasing acetylcholine at synapses. The usual neurological complications of OPI compounds are acute cholinergic crisis, intermediate syndrome, and delayed sensorimotor polyneuropathy. Extrapyramidal symptoms, though very rare, can also occur following OPI exposure. Parkinsonism is a movement disorder that develops as a consequence of reduced function of the dopaminergic neurons within the basal ganglia. The etiology of parkinsonism is multifactorial, with both genetic and environmental determinants. The development of typical parkinsonism following brief inhalational OPI exposure is very rare and there are only a few reports in the literature. We report a 50-year-old male who presented with cholinergic crisis following acute accidental inhalational exposure to chlorpyriphos, an OPI compound; he developed features of parkinsonism on day 6 of hospital admission, but recovered completely without treatment in 7 days.


How to cite this article:
Kumar AP, Subrahmanyam D. Acute reversible Parkinsonism following accidental exposure to organophosphate insecticide.Int J Nutr Pharmacol Neurol Dis 2013;3:70-72


How to cite this URL:
Kumar AP, Subrahmanyam D. Acute reversible Parkinsonism following accidental exposure to organophosphate insecticide. Int J Nutr Pharmacol Neurol Dis [serial online] 2013 [cited 2021 Jan 27 ];3:70-72
Available from: https://www.ijnpnd.com/article.asp?issn=2231-0738;year=2013;volume=3;issue=1;spage=70;epage=72;aulast=Kumar;type=0