International Journal of Nutrition, Pharmacology, Neurological Diseases

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 1  |  Issue : 2  |  Page : 179--183

A pathomorphological study of the sublethal toxicity of cypermethrin in Sprague Dawley rats


Remya R Nair1, Mammen J Abraham3, CR Lalithakunjamma3, N Divakaran Nair3, CM Aravindakshan2 
1 Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Sultanate of Oman;Center of Excellence in Pathology, College of Veterinary and Animal Sciences, Thrissur, Kerala,India
2 Center of Excellence in Pathology and Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Thrissur, Kerala, India

Correspondence Address:
Remya R Nair
Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, PO.Box 34, PC. 123, Sultan Qaboos University, Sultanate of Oman

Introduction : A study was undertaken to investigate the potential toxic effects of cypermethrin in adult Sprague Dawley male rats, with particular emphasis on its effect on the nervous and digestive systems. Materials and Methods: The clinical signs, gross and histological alterations were analyzed, to study the effects of different doses of cypermethrin. Results: Medium and high doses produced nervous signs in animals. Gross lesions were observed in the intoxicated groups, such as, bloat, congestion of lungs, heart, brain, pulmonary haemorrhage, and degenerative changes in the liver and kidneys. Microscopically effects on all organs were mild-to moderate degenerative changes at the low-dose level. Medium- and high-dose intoxicated groups revealed necrotic changes, extensive haemorrhages, congestion in organs like liver, kidney, and lungs apart from the changes observed in low-dose group animals. Conclusions: The text to abstract): The present study reveals that cypermenthrin can produce toxic effects in mammals at sublethal doses.


How to cite this article:
Nair RR, Abraham MJ, Lalithakunjamma C R, Nair N D, Aravindakshan C M. A pathomorphological study of the sublethal toxicity of cypermethrin in Sprague Dawley rats.Int J Nutr Pharmacol Neurol Dis 2011;1:179-183


How to cite this URL:
Nair RR, Abraham MJ, Lalithakunjamma C R, Nair N D, Aravindakshan C M. A pathomorphological study of the sublethal toxicity of cypermethrin in Sprague Dawley rats. Int J Nutr Pharmacol Neurol Dis [serial online] 2011 [cited 2021 Apr 13 ];1:179-183
Available from: https://www.ijnpnd.com/article.asp?issn=2231-0738;year=2011;volume=1;issue=2;spage=179;epage=183;aulast=Nair;type=0