International Journal of Nutrition, Pharmacology, Neurological Diseases

LETTER TO EDITOR
Year
: 2011  |  Volume : 1  |  Issue : 1  |  Page : 82--83

Biotechnology: The novel drug delivery system


Rajiv Saini1, Santosh Saini2, RS Sugandha3,  
1 Department of Periodontology & Oral Implantology, Rural Dental College, Loni, Maharashtra, India
2 Department of Microbiology, Rural Dental College, Loni, Maharashtra, India
3 Department of Prosthodontics, Rural Dental College, Loni, Maharashtra, India

Correspondence Address:
Rajiv Saini
Department of Periodontology & Oral Implantology, Rural Dental College, Loni, Tehsil- Rahata, District- Ahmednagar, Maharashtra - 413 736
India




How to cite this article:
Saini R, Saini S, Sugandha R S. Biotechnology: The novel drug delivery system.Int J Nutr Pharmacol Neurol Dis 2011;1:82-83


How to cite this URL:
Saini R, Saini S, Sugandha R S. Biotechnology: The novel drug delivery system. Int J Nutr Pharmacol Neurol Dis [serial online] 2011 [cited 2021 Sep 17 ];1:82-83
Available from: https://www.ijnpnd.com/text.asp?2011/1/1/82/77539


Full Text

Sir,

The approach of biotechnological techniques for the fabrication of drugs brought a mutiny to the pharmaceutical field. Biotechnology allows bespoke production of biopharmaceuticals and biotechnological drugs; however, many of them require special formulation technologies to overcome drug-associated problems. Such probable challenges to solve are as follows: poor solubility, limited chemical stability in vitro and in vivo after administration (i.e., short half-life), poor bioavailability, and potentially strong side effects requiring drug enrichment at the site of action. Drug delivery is becoming a whole interdisciplinary and independent field of research and is gaining the attention of pharmaceutical makers, medical doctors, and industry. A targeted and safe drug delivery could improve the performance of some classical medicines already on the market and, moreover, will have implications for the development and success of new therapeutic strategies, such as peptide and protein delivery, glycoprotein administration, gene therapy, and RNA interference. Many innovative technologies for effective drug delivery have been developed, including implants, nanotechnology, cell and peptide encapsulation, microfabrication, chemical modification, and others. On the long way from the clinic to market, however, several issues will have to be addressed, including suitable scientific development, specific financial support as a result of altered scientific policy, government regulations, and market forces. [1] Medication delivery systems that concentrate medications only where needed and used could reduce the destruction of surrounding tissues while minimizing side effects. The benefits of such systems in the treatment of both acute and chronic conditions are clear. Because research demonstrates that patient adherence is improved when side effects are minimized, it is imperative that drug delivery systems efficiently and precisely deliver medications in a manner that the patient finds acceptable and tolerable. Patients themselves are demanding drug delivery systems that are convenient, easy to use, and affordable. Progress in the development of novel drug delivery systems is bringing researchers and clinicians closer to meeting the goals of maximum efficacy with minimal toxicity and inconvenience. [2] Nanotechnology, or systems or devices manufactured at the molecular level, is a multidisciplinary scientific field undergoing explosive development. A part of this field is the development of nanoscaled drug delivery devices. Nanoparticles have been developed as an important strategy to deliver conventional drugs, recombinant proteins, vaccines, and more recently nucleotides. Nanoparticles and other colloidal drug delivery systems modify the kinetics, body distribution, and drug release of an associated drug. Other effects are tissue- or cell-specific targeting of drugs and the reduction of unwanted side effects by a controlled release. Therefore, nanoparticles in the pharmaceutical biotechnology sector improve the therapeutic index and provide solutions for future delivery problems for new classes of so called biotech drugs including recombinant proteins and oligonucleotides. [3] The potential nanotechnology in the field of pharmaceutical biotechnology will positively affect medical and pharmaceutical science in all areas. Improved diagnostics will allow not only working with Point-of-Care devices close to the patients, but also to combine diagnostic and therapeutic actions in a nanoscaled drug delivery systems. Interest and investments in this area will continue to provide contemporary and profound medical applications. [3] Therefore, biotechnological drugs swathe all drugs created by a biotechnological procedure, e.g., fermentation, enzyme, hybridoma, tissue and cell culture technology, and genetic engineering.

References

1Orive G, Hernández RM, Gascón AR, Gil AD, Pedraz JL. Drug delivery in biotechnology: Present and future. Curr Opin Biotechnol 2003;14:659-64.
2Berkowitz AC, Goddard DM. Novel drug delivery systems: Future directions. J Neurosci Nurs 2009;41:115-20.
3Kayser O, Lemke A, Trejo NH. The impact of nano biotechnology on the development of new drug delivery systems. Curr Phrama Biotech 2005;6:3-5.