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REVIEW ARTICLE
Year : 2021  |  Volume : 11  |  Issue : 4  |  Page : 255-261

Managing the Cytokine Storm in COVID-19: Can Melatonin Play a Part?

Aruna Ganganna1, Byalakere Rudraiah Chandrashekar2, Madhugiri Prakash Venkatesh3, Uzma Belgaumi4, Sachin Shivnaikar5, Purnima Bhandari6
1 Department of Periodontology, JSS Dental College and Hospital, Mysore, Karnataka, India
2 Public Health Dentistry, JSS Dental College and Hospital, Mysore, Karnataka, India
3 Department of Pharmaceutics, JSS College of Pharmacy, Mysore, Karnataka, India
4 Department of Oral Pathology, School of Dental Sciences, Krishna Institute of Medical Science, Karad, Maharashtra, India
5 Department of Periodontology, Maratha Mandal Institute of Dental Sciences, Belgaum, Karnataka, India
6 Department of Periodontology, Government Dental College and Hospital, Bangalore, Karnataka, India

Correspondence Address:
Aruna Ganganna
Department of Periodontology, JSS Dental College, Mysuru 570015
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnpnd.ijnpnd_53_21

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Some drugs with immunomodulatory and anti-inflammatory activity are identified as adjunctive therapy in the coronavirus disease 2019 (COVID-19) infections and researchers believe that such pathophysiologic pathway treatment approach is rational and important for future development of new therapeutic agents in managing this pandemic. This review will discuss various cytokines which go berserk and cause serious life-threatening complications in COVID-19 infections. Additionally, different therapeutic modalities in managing “cytokine storm,” with a special note on melatonin is discussed. The foundation laid by scientists on this wonder molecule may pave the path toward development of drug with satisfactory results either used alone or as an adjunct to other drugs. However, calming the angered cytokine profile seems pivotal during management of the devastating storm.


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