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NEUROLOGICAL DISEASES - ORIGINAL ARTICLES
Year : 2021  |  Volume : 11  |  Issue : 3  |  Page : 242-248

Effect of Centella asiatica L. Extract on Apoptosis and Bcl-2 Immunoexpression of Pyramidal Cells in Traumatic Brain Injury Rat Model


1 Department of Histology, Faculty of Medicine, Jenderal Soedirman University, Purwokerto, Central Java, Indonesia
2 Department of Anesthesiology, Faculty of Medicine, Jenderal Soedirman University, Purwokerto, Indonesia
3 Department of Anatomical Pathology, Faculty of Medicine, Jenderal Soedirman University, Purwokerto, Indonesia

Correspondence Address:
Nafiisah
Departement of Histology, Faculty of Medicine, Jenderal Soedirman University. Jl. Dr. Gumbreg, East Purwokerto, Banyumas, Central Java
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnpnd.ijnpnd_3_21

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Background: Traumatic brain injury therapy still has many shortcomings. The slow repair of post-traumatic pyramidal cells causes the need to find new alternatives to deal with the consequences of traumatic brain injury. This study aims to determine the effect of Centella asiatica L. extract in increasing pyramidal cells repair, assessed from the apoptosis and B-cell lymphoma 2 (Bcl-2) immunoexpression of pyramidal cells in traumatic brain injury rat model. Methods: This research was conducted during July 3–17, 2020 and used a true experimental research design with a posttest-only controlled group design. Rats were divided into five groups, that is, normal group, group treated with traumatic brain injury, and groups treated with traumatic brain injuries and given extracts of C. asiatica (L.) dose of 150, 300, and 600 mg/kg bw/day. Brains from each group were taken to examine the apoptosis and Bcl-2 immunoexpression of pyramidal cells at day 7. This study used Kruskal–Wallis test and post hoc Mann–Whitney test. Results: Based on the statistical analysis results, there was a significant correlation between the Bcl-2 immunoexpression and apoptosis of pyramidal cells in traumatic brain injury rat model with different doses of C. asiatica (L.) extract (P < 0.05). Dose of 600 mg/kgBW was the most effective in decreasing apoptosis and increasing Bcl-2 immunoexpression of pyramidal cells in traumatic brain injury rat model. Conclusion: This study proved that C. asiatica (L.) extract can decrease apoptosis and increase Bcl-2 immunoexpression of pyramidal cells in traumatic brain injury rat model.


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