| PHARMACOLOGY - ORIGINAL ARTICLES |
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| Year : 2021 | Volume
: 11
| Issue : 3 | Page : 211-219 |
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To Evaluate the Implementation and Impact of an Antimicrobial Stewardship at a Tertiary Care Teaching Hospital in India
Sweta Kumari1, Kavita Dhar Bagati2, Bala Krishnan Sadasivam3, Gudise Chitti Babu4
1 Department of Pharmacology, Santosh Medical College, Ghaziabad, Uttar Pradesh, India
2 Department of Pharmacology, School of Medical Sciences and Research, Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India
3 Department of Pharmacology, All Institute of Medical Sciences, Bhopal, India
4 JNU Hospital and Medical College, Jagatpura, Jaipur, Rajasthan, India
Correspondence Address:
Kavita Dhar Bagati
Department of Pharmacology, School of Medical Sciences and Research, Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijnpnd.ijnpnd_4_21
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Background: Antimicrobial stewardship programs refer to antibiotic policies, antibiotic management programs, and antibiotic control programs. According to the Centers for Disease Control and Prevention (CDC) Project ICARE, all hospitals reported having an antibiotic formulary, and 91% used at least one other antimicrobial control strategy. Materials and Methods: The present study is a retrospective and observational study. All information was noted and surveyed sporadically. Any deviations from the agreed criteria were communicated, discussed, and documented. Antibiotic stewardship started from an inpatient setting. In the first phase, the patient pool from inpatient was addressed. For the prospective audit, two components had been recognized to have an evidence level 1. These were multidisciplinary rounds of infectious diseases patients and the use of antimicrobials. Result: In Medicine ward, the most common class of drugs was beta-lactam; in beta-lactam, a combination of piperacillin/tazobactam, amoxicillin/clavulanic acid, and macrolides was used with a mean dose of 1408.18 g. While in orthopedics, most common drugs for prophylaxis use were found to be cephalosporins (cefazolin first generation) with a mean dose of 937.07 ± 741.81 g to reduce surgical site infections. Prophylactic use of beta-lactam (amoxicillin/clavulanic acid) was prescribed for the most of the cases of Ears, Nose and Throat (ENT) surgery with mean dose of 1019.63 g as well as in pediatrics with mean dose of 579.47 g. Conclusions: Antimicrobial stewardships have a significant impact on the reduction of targeted and empiric antibiotic use, healthcare costs, and antimicrobial resistance in inpatient settings.
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