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ORIGINAL ARTICLE
Year : 2021  |  Volume : 11  |  Issue : 1  |  Page : 50-56

A Novel Herbal Combination Decreased Lipid Droplets Accumulation and Cytokines Levels During Adipogenesis by Regulating Leptin, PPARγ and SREBP1c Genes Expression in 3T3L1 Cells


1 Department of anatomical sciences, School of Medicine, St. George’s University Grenada, West Indies
2 Department of biomedical sciences, School of Medicine, Nazarbayev University Nur-Sultan, Kazakhstan
3 Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, India

Correspondence Address:
Arehally M Mahalakshmi
School of Medicine, St. George’s University Grenada, West Indies. & Arehally M. Mahalakshmi, Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru
India
Vasavi Rakesh Gorantla
Department of Anatomical Sciences, School of Medicine, St. George’s University Grenada, West Indies

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnpnd.ijnpnd_88_20

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The present study aims at demonstrating the anti-adipogenesis and anti-inflammatory of combination of extracts of commiphora wightti, curcuma longa, and tinospora cordifolia using mouse 3T3-L1 cells. Herbal formula (CCT) significantly suppressed the mRNA of PPARγ, leptin, and SREBP1c expression, which is reveals its significant anti-adipogenesis activity. In addition, CCT down-regulated TNFα and iNOS expression, this is an added advantage and helps to alleviate the inflammatory reactions during adipogenesis. These findings encourage for further studies using in vivo models of obesity and associated complications.


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