| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 10
| Issue : 3 | Page : 149-153 |
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The Dosage of the Avocado Leaf Extract (Persea americana Mill.) on Regeneration of Diabetic White Rats (Rattus norvegicus) Renal Cell
Nurdin Rahman1, Sri Mulyani Sabang2, Nikmah Utami Dewi1, Bohari1, St. Ika Fitrasyah1
1 Faculty of Public Health, Nutrition Department, Tadulako University, City of Palu, Indonesia
2 Chemistry Education, Faculty of Teacher Training and Education, Tadulako University, City of Palu, Indonesia
Correspondence Address:
Nurdin Rahman
Soekarno Street Km 9, City of Palu, Indonesia
Indonesia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijnpnd.ijnpnd_6_20
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Context: Antioxidant activity in avocado leaves plays a role in improving insulin work in controlling blood glucose levels. Aim: To analyse the effect of doses of avocado leaf extract on the regeneration of diabetic rat renal cells. Methods: Experimental method was used with 18 male white rats as subjects. White rats were divided into six groups: Treatment G1: Feed + STZ (Streptozotocin) + Sucrose 10% + Avocado leaf extract dose of 100 mg/kg body weight + NaCMC 0.5%, G2: Feed + STZ + Sucrose 10% + Avocado leaf extract 150 mg/kg body weight + NaCMC 0.5%, G3: Feed + STZ + Sucrose 10% + Avocado leaf extract dose 200 mg/kg body weight + Na-CMC 0.5%, G4: Feed + STZ + 10% sucrose + Na-CMC 0.5%, G5: Feed + STZ + 10% sucrose + Glibenclamid + Na-CMC 0.5%, and P6: Feed. Results: The average renal damage of rats in the rat group was G1 = 1.66; G2 = 1.33; G3 = 0; G4 = 3; P5 = 0; P6 = 0. Score 0 = no damage. Score 1 = mild renal cell damage (1/3 cell part); score 2 = moderate renal cell damage (2/3 cell parts); score 3 = severe renal cell damage (>2/3 cell parts). Conclusion: The treatment of G3 with a dose of 200 mg/kg body weight avocado leaf extract gives a relatively effective influence on regenerating STZ induced renal cell rats, compared to other doses.
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