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Year : 2020  |  Volume : 10  |  Issue : 3  |  Page : 144-148

Prevalence and Severity of Adverse Drug Reactions Among Patients Receiving Antipsychotic Drugs in a Tertiary Care Hospital

Department of Pharmacology, KAHER’s Jawaharlal Nehru Medical College, Belagavi, Karnataka, India

Correspondence Address:
Assistant Professor Netravathi Basavaraj Angadi
Department of Pharmacology, KAHER’s Jawaharlal Nehru Medical College, Belagavi, Nehru Nagar, Belagavi – 590010
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnpnd.ijnpnd_9_20

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Aims: Adverse drug reactions are usually dose dependent and can be influenced by patient characteristics including age and gender and these confounding factors should be considered in clinical practice and in the interpretation of research data. This study was planned to evaluate the profile of adverse drug reactions among patients receiving antipsychotic drugs in a tertiary care hospital and to assess the severity of adverse drug reactions. Methods: It was a hospital-based cross-sectional study, conducted in Department of Psychiatry in a tertiary care hospital. An assessment of severity was done using modified Hartwig and Siegel scale. Categorical variables were summarized as percentages. Chi-square test was used to test for independence of two categorical variables. P < 0.05 was considered as statistically significant. Results: The overall prevalence of ADRs in the study population was found to be 51.9%. When the percentage of individual ADRs was taken into consideration, the most common ADR was increase in weight (15.7%) followed by sedation (9.6%), increased appetite (7.8%), Rigidity (6.8%) and akathesia (5.1%) As per modified Hartwig and Siegel scale for assessing the severity of ADRs, 34(63.0%) ADRs were mild in severity and 20 (37.0%) ADRs were moderate in severity. Conclusion: ADRs occur quite frequently in these patients receiving antipsychotic drugs, which are often mild in nature Thus, the recognition of these side-effects and their management can ensure optimal care for the patient.

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