Users Online: 263

Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 
Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 35-40

Attenuation of Aluminum-Induced Neurotoxicity by Tannoid Principles of Emblica officinalis in Wistar Rats

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India

Correspondence Address:
Arokiasamy Justin Thenmozhi
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnpnd.ijnpnd_23_18

Rights and Permissions

Introduction: In our earlier studies, we reported the neuroprotective effect of tannoid principles of Emblica officinalis (EoT) against aluminum chloride (AlCl3)-induced neurotoxicity in the hippocampus and cortex of rats. The present study is focused on the efficacy of EoT in the mitigation of AlCl3-induced toxicity in the cerebellum. Materials and Methods: Rats were randomly divided into four groups and treated with AlCl3 (100 mg/kg, b.w. i.p.), EoT (100 mg/kg, b.w. oral), and simultaneously with AlCl3 and EoT daily for 60 days. Results: AlCl3 treatment altered the body weight, brain and cerebellum weight, Al levels, acetylcholinesterase activity, and the expression of apoptotic markers. Treatment with EoT attenuated these physiological, biochemical, and molecular indices. Conclusion: The results of the present study strengthen the fact that the nutritional supplement of EoT in AlCl3-treated rats might improve the adverse effects by its pharmacological properties.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded187    
    Comments [Add]    

Recommend this journal