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Year : 2018  |  Volume : 8  |  Issue : 1  |  Page : 3-9

Attenuation of Arsenic-Induced Dyslipidemia by Fruit Extract of Emblica Officinalis in Mice

1 Department of Biochemistry, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India
2 Department of Pharmacology, King George’s Medical University, Lucknow, Uttar Pradesh, India
3 Department of Pharmacology, All Institute of Medical Sciences, Jodhpur, Rajasthan, India
4 Department of Criminology and Forensic Science, School of Applied Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, India

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnpnd.ijnpnd_69_17

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Introduction: In our earlier studies, we reported that arsenic-induced enhanced oxidative stress, apoptosis, immunotoxicity and inflammation in the spleen and thymus of mice and hepatotoxicity have been protected through treatment with Emblica officinalis (amla). The present study is focused on to the efficacy of amla in mitigation of arsenic-induced dyslipidemia and alterations in inflammatory biomarkers in the blood of mice. Materials and Methods: Mice were randomly divided into four groups and treated with sodium arsenite (3 mg/kg b.w., per os), amla (500 mg/kg b.w., per os) and simultaneously with arsenic and amla daily for 30 days. Results: Arsenic treatment altered the hematological and lipid profile by increasing total cholesterol (TC), triglyceride (TG), phospholipid (PL) and low-density lipoprotein (LDL) levels and decreasing high-density lipoprotein (HDL) levels as compared to controls. Treatment with arsenic also disturbed the levels of inflammatory biomarkers. Concurrent treatment with arsenic and amla significantly restored serum TC level (0.83-fold), TG level (0.92-fold), LDL level (0.72-fold), PL level (1.29-fold), and increased HDL level (1.4-fold). Inflammatory cytokine levels were also corrected significantly as serum interleukin-8 level (0.6-fold) and C-reactive protein level decreased (0.7-fold) respectively, while interleukin-10 level was increased (1.5-fold) as compared to those treated with arsenic alone. The alterations in hematological parameters were also found to be normalized by treatment of amla. Conclusion: The results of the present study strengthen the fact that nutritional supplement of amla in arsenic affected areas might improve the adverse effects of arsenic on lipid profile.

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