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Year : 2017  |  Volume : 7  |  Issue : 4  |  Page : 94-100

Validation of Fat-Free Mass Estimation Using Prediction Equations in Male Patients with Chronic Obstructive Pulmonary Disease

1 Department of Studies in Food Science & Nutrition, University of Mysore, Mysuru, Karnataka, India
2 Department of Pulmonology, JSS Medical College, JSS University, Mysuru, Karnataka, India

Correspondence Address:
Asna Urooj
Department of Studies in Food Science & Nutrition, University of Mysore, Manasagangotri, Mysuru - 570 006, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnpnd.ijnpnd_37_17

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Context: The use of predictive equations in hospital settings lacking access to dual energy X-ray absorptiometry or bioelectrical impedance analysis (BIA) can be beneficial because cachexia, muscle wasting and related increase in morbidity and mortality are known occurrences in patients with chronic obstructive pulmonary disease (COPD). Aim: To analyse the predictive performance of reported equations for fat-free mass (FFM) prediction against BIA-derived FFM in patients with stable COPD. Design/Materials and Methods: Seventy-two male patients aged between 40 and 75 years with stable COPD were evaluated for FFM by BIA. FFM was also predicted for the same patients using equations reported by Kulkarni et al., Solomon Yu et al., Janmahasatian et al., as well as Deurenberg equation. Statistical Analysis Used: The predictive performance was assessed by Bland–Altman plots, with subsequent calculations of bias, precision and accuracy. The performance was also analysed across the age and body mass index sub-groups. Results: The mean differences (95% confidence intervals) in the prediction of FFM using equations by Kulkarni et al. and Deurenberg equation were −0.33 kg (−4.910, 4.258) and 0.31 kg (−3.330, 3.946), respectively. The equation by Solomon Yu et al. and Janmahasatian et al. overestimated FFM with a mean difference of 3.99 kg (−2.449, 10.428) and 3.76 kg (−0.443, 7.956), respectively. Conclusion: The equation by Kulkarni et al. provides an acceptable prediction of FFM in patients who were underweight or had normal weight with COPD and were aged between 50 and 69 years. The Deurenberg equation was used to predict FFM in patients aged between 40–49 and 60–75 years. Further validation of the predictive performance in overweight and obese COPD patients is required.

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