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ORIGINAL ARTICLE
Year : 2017  |  Volume : 7  |  Issue : 4  |  Page : 101-106

Effect of Myricetin on the Oxidative Stress Markers in the Brain of Transgenic Flies Expressing Human Alpha-Synuclein


1 Human Genetics and Toxicology Laboratory, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
2 Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

Correspondence Address:
Yasir H Siddique
Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnpnd.ijnpnd_41_17

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Background: Parkinson’s disease (PD) is a neurodegenerative disorder having no permanent cure, but there has been a great deal of interest in finding the role of complementary and alternative medicines for the treatment of neurodegenerative disorders. Oxidative stress has also been implicated in the progression of PD. Objective: Since ancient time, natural plant products have been studied for their protective action. In this study, the effect of myricetin was studied on transgenic flies expressing human alpha-synuclein in the neurons. Materials and Methods: The PD flies were allowed to feed on a diet supplemented with 5, 10, and 20 μM of myricetin for 24 days. The flies with PD were then subjected to the study of oxidative stress markers. Results: The results of this study reveal that the exposure of flies with PD to myricetin showed a significant dose-dependent decrease in oxidative stress compared to unexposed flies with PD (P < 0.005). Conclusion: Myricetin is potent in reducing oxidative stress in the brain of flies with PD induced by the expression of human alpha-synuclein and the formation of Lewy bodies.


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