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Year : 2015  |  Volume : 5  |  Issue : 4  |  Page : 128-134

Differential regulation of volatile anesthetics on ion channels

Department of Zoology, Nizam College, Hyderabad, Telangana, India

Correspondence Address:
Senthilkumar Rajagopal
Department of Zoology, Nizam College, Hyderabad - 500 001, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.167501

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Pain processes are regulated by voltage-gated calcium channels (VDCC) and Ca2+. Many mediators of pain increase Ca2+ influx through calcium channels, leading to a significant increase in intracellular calcium ([Ca2+]i). Calcium channels act as integrators of G-protein-mediated signalling in neurons. Phosphorylation of calcium channels primary subunits by kinases such as protein kinase C (PKC) and tyrosine kinases have been shown to inhibit/enhance Cavchannels. Increased/decreased Cavcurrents and PKC activations observed in in vivo pain investigations, and a Xenopus oocytes model may serve as an in vitro model for some cellular mechanisms of pain. In this review, we focus on anesthetic and PKC regulations on ion channels and their properties.

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