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Year : 2015  |  Volume : 5  |  Issue : 1  |  Page : 40-42

Nicotine dependence in resistant schizophrenia: A compensation for trihexyphenidyl dependence or just comorbidity

Department of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Sujita Kumar Kar
Department of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.150076

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A 42-year-old male, suffering from schizophrenia with nicotine dependence and on regular treatment, had reported the overuse of trihexyphenidyl (40-50 mg/day) for the last 2 years in a dependence pattern, which was temporally correlated with increased consumption of nicotine over the same time frame. The patient used to report withdrawal symptoms and craving for trihexyphenidyl, when it was not available. This case report attempts to discover the possible links between nicotine dependence and trihexyphenidyl dependence in schizophrenia with emphasis on the compensatory measure to counter the imbalance in cholinergic system.

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