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Year : 2014  |  Volume : 4  |  Issue : 4  |  Page : 246-251

Antidepressant effect of linseed oil on various behavioral and pharmacological models of depression in Swiss albino mice

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, Maharashtra, India

Correspondence Address:
Sadhana Sathaye
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400 019, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.139407

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Background: Linum usitatissimum Linn. (Linaceae) commonly known as linseed or flaxseed is known to be the richest plant source for alpha-linoleic acid, an omega-3 fatty acid. Aim: The objective of the present study was to evaluate the oil extracted from Linseed (LO) for anti-depressant activity in mice. Materials and Methods: Healthy male Swiss albino mice were randomly divided into five groups as follows: (i) Control, (ii) LO (4 ml/kg b.w./day), (iii) LO (8 ml/kg/day), (iv) Fish oil (FO) equivalent to 300 mg/kg/day of Docosahexaenoic acid (DHA), and (v) Standard (Imipramine). The antidepressant effect was evaluated using behavioral models like the Despair swim test (DST) and Tail suspension test (TST), and pharmacological models like potentiation of norepinephrine toxicity, 5-hydroxytryptophan potentiation, tetrabenazine antagonism, and apomorphine-induced cage climbing. Fluorimetric estimation of norepinephrine, dopamine, and 5-hydroxytryptophan levels in the brain was also carried out. Results: In case of behavioral models, LO at 0.2 ml/mice/day, significantly reduced the immobilization time. A significant antidepressant activity of LO was found in the pharmacological models. This was confirmed by the elevated levels of norepinephrine and dopamine in the brains of LO-treated animals, as compared to control animals. Conclusion: Linseed oil showed a significant antidepressant effect in various experimental models of depression in Swiss mice, which seemed most likely to be mediated through an interaction with the adrenergic and dopaminergic systems.

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