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Year : 2014  |  Volume : 4  |  Issue : 4  |  Page : 224-230

Evaluation of ethanolic extract of Cucumis melo L. for inflammation and hyperplasia of prostate

Department of Pharmacology, University College of Pharmacy, Cheruvandoor Campus, Kottayam, Kerala, India

Correspondence Address:
Sibi P Ittiyavirah
Department of Pharmacology, University College of Pharmacy, Cheruvandoor Campus, Kottayam - 686 631, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.139403

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Aim: The hypothesis of the current study is to evaluate the therapeutic potential of ethanolic extract from Cucumis melo L to act as an anti-inflammatory and anticancer agent on the protate gland. Materials and Methods: The study was evaluated by performing various in vitro and in vivo experiments with wistar albino rats. The statistical analysis was carried out using one-way ANOVA followed by Dunnett's multiple comparisons for the data which were normally distributed. Results: The ethanolic extract of Cucumis melo L. (EECM) shows reduction in hyperplasia of the prostate which is observed by the decrease in total weight when compared to the positive control and hence is beneficial in benign prostatic hyperplasia (BPH) and also possesses apoptotic activity which is observed by acridine orange and ethidium bromide double staining and then visualized by Fluorescent microscopy. The result showed that the ethanolic extract is capable of reducing the prime inflammatory mediator TNF-α and hence reduces inflammation.

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