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Year : 2014  |  Volume : 4  |  Issue : 3  |  Page : 139-145

Toxicological assessment of Pleurotus ostreatus in Sprague Dawley rats

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Chidambaram, Tamil Nadu, India

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Source of Support: UGC Major Research Project., Conflict of Interest: None

DOI: 10.4103/2231-0738.132665

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Objective: To evaluate toxicological and histopathological assessment of Pleurotus ostreatus, an oyster mushroom in Sprague Dawley rats. Materials and Methods: Toxicity assessment was carried out by acute (72 h) and sub acute toxicity (28 days) studies and also its effects on hepatic marker enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) and renal markers enzymes (urea, uric acid, and creatinine) in blood serum and liver histology of experimental Sprague Dawley rats was performed. Results: The studies indicated that the LD 50 value was found to be >5,000 mg/kg body weight (b.wt). The body weight and general behaviors of animals were observed throughout the experimental period and at end of the study, organ weight, biochemical parameters of blood (serum) as well as liver histology indicated that no toxic clinical symptoms or histopathological changes were observed in experimental Sprague Dawley rats. Conclusion: The above studies clearly indicated that the P. ostreatus extract had high margin of safety.

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