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Year : 2012  |  Volume : 2  |  Issue : 3  |  Page : 217-222

Biochemical changes in cardiac tissue upon monosodium glutamate administration in hypercholestremic mice

1 Department of Biochemistry, Govt. Medical College- Amritsar, India
2 Department of Horticulture, Punjab Agricultural university-Ludhiana, India
3 Department of Biochemistry, Panjab University-Chandigarh, India

Correspondence Address:
Kuldip Singh
House No. B-2, Govt. Medical College Campus, Amritsar, Punjab
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.99473

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Background: Monosodium glutamate, a flavour enhancer ubiquitously used all over the World as a flavour enhancer in a variety of foods like two minute noodles, soups, sauces etc. prepared at home or restaurants. Aim:Monosodium glutamate was administrated at dose levels of 4 and 8mg/g body weight to hypercholestremic adult male mice for 6 consecutive days and its effect was observed on 31 st day after the last injection for the genesis of atherosclerosis by evaluating the changes in plasma lipid peroxidation and certain antioxidant enzymes in cardiac tissue of hypercholestremic adult male mice. Materials and Methods: The animals were divided in four groups each comprising 6 mice. Group-I: Control, Group-II: Hypercholestremic animals, Group-III: 4mgMSG/g body weight + hypercholestremic animals and Group-IV: 8mgMSG/g body weight + hypercholestremic animals. Animals were fasted overnight and sacrificed by decapitation. The 10% homogenate was prepared in 100mMpotassium phosphate buffer (pH7.5). The homogenate was centrifuged at 1,000g and supernatant was used for the estimation of lipid peroxidation, xanthine oxidase, superoxide dismutase and catalase. Results:A significant increase was observed in lipid peroxidation and xanthine oxidase levels while a significant decrease was found in superoxide dismutase and catalase levels of all the studied groups. Conclusion: These observations suggested that administration of monosodium glutamate at dose levels of 4 mg/g body weight and above to hypercholestremic animals had no beneficial effect instead it further enhanced the lipid peroxidation and alter the status of free radical initiating (xanthine oxidase) and scavenging (superoxide dismutase and catalase) enzymes and thereby being responsible for the initiation of coronary heart disease/atherosclerosis.

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