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Year : 2011  |  Volume : 1  |  Issue : 2  |  Page : 163-166

Effect of N-phthaloyl gamma-aminobutyric acid on lipid peroxidation, antioxidants and liver markers in constant light exposed rats

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India

Correspondence Address:
Perumal Subramanian
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.84208

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Introduction & Materials and Methods : The effect of N-Phthaloyl GABA on the levels of circulatory lipid peroxidation products such as TBARS (thiobarbituric acid reactive substances), antioxidants: SOD (superoxide dimutase), CAT (catalase), GSH (reduced glutathione), and GPx (glutathione peroxidase), liver markers such as AST (aspartate transaminase), ALT (alanine transaminase), and ALP (alkaline phosphatase), were studied for its protective effect during constant light (LL) exposure in rats. Results: A significant increase in the levels of circulatory TBARS, AST, ALT, and ALP were found in LL exposed rats. These changes were significantly decreased in N-Phthaloyl GABA and LL-exposed rats. The levels of antioxidants were significantly decreased in LL-exposed rats and administration of GABA normalized these changes. Conclusions: Our results indicated that NPhthaloyl GABA offered protection by influencing the levels of the lipid peroxidation products, antioxidants, and liver markers during LL-exposed stress. This might be due to the antistress, anticonvulsant, antinociceptive, and antiulcer activities of N-Phthaloyl GABA. The exact mechanism remains to be explored and further research is needed.

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