| ORIGINAL ARTICLE |
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| Year : 2011 | Volume
: 1
| Issue : 2 | Page : 146-151 |
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Tephrosia purpureaLinn leaves attenuate pain and inflammation in experimental animals
Vishal Gulecha1, Thangavel Sivakumar2, Aman Upaganlawar3, Rakesh Khandare3, Chandrashekhar Upasani3
1 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik; Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamil Nadu, India
2 Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamil Nadu, India
3 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik, India
Correspondence Address:
Vishal Gulecha
Department of Pharmacology, SNJB'S SSDJ College of Pharmacy Neminagar, Chandwad, Nashik
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2231-0738.84205
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Aim : Present study evaluates the analgesic and anti-inflammatory activities of different fractions of Tephrosia purpurea using various experimental models. Materials and Methods: The analgesic activity of T. purpurea carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-granuloma formation in rats. The effects of the administration of reference standard (Ibuprofen and hydrocortisone) were also evaluated. Results: Five different fractions (TPI, TPII, TPIII, TPIV, and TPV) of T. purpurea at the dose level of 20 and 40 mg/kg, p.o. were tested. The fraction TPI (40 mg/kg, p.o.) and TPIII (40 mg/kg, p.o.) were found to be more effective in preventing carrageenan induced rat paw edema, cotton pellet granuloma formation and acetic acid-induced writhing; however, TPI (20 mg/kg, p.o.) and TPIII (20 mg/kg, p.o.) were found to be more effective in increasing latency period in tail flick method. Conclusions: Out of five different fractions of T. purpurea tested, TPI and TPIII possess potent analgesic and anti-inflammatory activities against different models of inflammation and pain. |
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