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Year : 2011  |  Volume : 1  |  Issue : 1  |  Page : 78-80

A case of neuroleptic malignant syndrome induced by desvenlafaxine in a patient on clozapine

1 Department of Psychiatry, KPC Medical College and Hospital, Kolkata, India
2 Department of Psychiatry , Calcutta National Medical College and Hospital, Kolkata, India
3 Department of Psychiatry , NRS Medical College and Hospital, Kolkata, Kolkata, India
4 Department of Cardiology, Calcutta National Medical College and Hospital, Kolkata, India, India

Correspondence Address:
Suddhendu Chakraborty
Department of Psychiatry, KPC Medical College and Hospital, Kolkata
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.77537

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Neuroleptic malignant syndrome is a rare and potentially serious syndrome associated with the use of many antipsychotic, antiparkinsonian, antidepressants, etc. Moreover, of the agents known to cause this entity, clozapine has been mentioned a fewer times, but desvenlafaxine has never been known to precipitate it. However in this study, we present a case of established Neuroleptic syndrome that precipitated after administration of desvenlafaxine in a patient of resistant schizophrenia who was on clozapine. The presenting case explores the possibility of the potential of desvenlafaxine in causing this rare clinical entity and also a possible idiosyncratic interaction between desvenlafaxine and clozapine, whose mechanism is yet to be known.

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