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  Indian J Med Microbiol
 

Figure 3 Immunohistochemical staining of articular tissue from different groups. (A) Section at the knee joint of the control group showing a negative reaction for cyclooxygenase (COX-2; ×200). (B) Section at the knee joint of the arthritic group with many cells exhibiting a positive cytoplasmic reaction (arrows) (COX-2; ×200). (C) Section at the knee joint of the OMEGA-treated group showing a positive reaction in some cells in the articular cartilage as well as in the synovial membrane (arrows) (COX-2; ×200). (D) Section at the knee joint of the DEX-treated group showing a positive reaction in few cells in the articular cartilage (arrows) (COX-2; ×200). (E) Section at the knee joint of the MTX-treated group showing a positive reaction in some cells in the articular cartilage (arrows) (COX-2; ×200). (F) Section at the knee joint of the OMEGA combined with the DEX-treated group showing a positive reaction in few cells in the articular cartilage (arrows) (COX-2; ×400). (G) Section at the knee joint of the OMEGA combined with the MTX-treated group showing a positive reaction in relatively few cells in the articular cartilage as well as in the synovial membrane (arrows) (COX-2; ×400). DEX, dexamethasone; MTX, methotrexate; OMEGA, omega-3.

Figure 3 Immunohistochemical staining of articular tissue from different groups. (A) Section at the knee joint of the control group showing a negative reaction for cyclooxygenase (COX-2; ×200). (B) Section at the knee joint of the arthritic group with many cells exhibiting a positive cytoplasmic reaction (arrows) (COX-2; ×200). (C) Section at the knee joint of the OMEGA-treated group showing a positive reaction in some cells in the articular cartilage as well as in the synovial membrane (arrows) (COX-2; ×200). (D) Section at the knee joint of the DEX-treated group showing a positive reaction in few cells in the articular cartilage (arrows) (COX-2; ×200). (E) Section at the knee joint of the MTX-treated group showing a positive reaction in some cells in the articular cartilage (arrows) (COX-2; ×200). (F) Section at the knee joint of the OMEGA combined with the DEX-treated group showing a positive reaction in few cells in the articular cartilage (arrows) (COX-2; ×400). (G) Section at the knee joint of the OMEGA combined with the MTX-treated group showing a positive reaction in relatively few cells in the articular cartilage as well as in the synovial membrane (arrows) (COX-2; ×400). DEX, dexamethasone; MTX, methotrexate; OMEGA, omega-3.