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  Indian J Med Microbiol
 

Figure 1: Synthetic route of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carboxylic acids; reagents and conditions: (a) Ammonium sulfamate, neat, 200°C, 20-24 h, 64%; (b) 4N HCl, 100°C, 1-2 h, 38%; (c) diethyl malonate, EtOH, reflux, 4-5 h, 60%; (d) POCl3, cat. DMF, 1-2 h, 67%; (e) K2CO3, acetonitrile, piperazines, 80°C, 1-2 h (f) 10% aq. NaOH, rt, 1 h, aq. citric acid

Figure 1: Synthetic route of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carboxylic acids; reagents and conditions: (a) Ammonium sulfamate, neat, 200°C, 20-24 h, 64%; (b) 4N HCl, 100°C, 1-2 h, 38%; (c) diethyl malonate, EtOH, reflux, 4-5 h, 60%; (d) POCl3, cat. DMF, 1-2 h, 67%; (e) K2CO3, acetonitrile, piperazines, 80°C, 1-2 h (f) 10% aq. NaOH, rt, 1 h, aq. citric acid