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  Indian J Med Microbiol
 

Figure 6: Inhibitory effect of SM on UVB radiation-induced MMP-9 and MMP-2 activation. Cells were harvested at 24 h after UVB exposure, and cell supernatants were prepared to determine the activation of MMP-9 and MMP-2 using gelatin zymography. UVB exposure increased the activation of both MPPs in HDFa, while SM treatment at concentrations of 8, 40 and 80 µM significantly down-regulated the intracellular MMP-9 and MMP-2 activation in a dose-dependent manner (compared with 0 mg/ml control group, P<0.05). Data represent the means ± SD of three individual experiments. *Significantly different from control cells (P<0.05). **Significantly different from UVB-exposed cells (P<0.05)

Figure 6: Inhibitory effect of SM on UVB radiation-induced MMP-9 and MMP-2 activation. Cells were harvested at 24 h after UVB exposure, and cell supernatants were prepared to determine the activation of MMP-9 and MMP-2 using gelatin zymography. UVB exposure increased the activation of both MPPs in HDFa, while SM treatment at concentrations of 8, 40 and 80 µM significantly down-regulated the intracellular MMP-9 and MMP-2 activation in a dose-dependent manner (compared with 0 mg/ml control group, <i>P</i><0.05). Data represent the means ± SD of three individual experiments. *Significantly different from control cells (<i>P</i><0.05). **Significantly different from UVB-exposed cells (<i>P</i><0.05)