International Journal of Nutrition, Pharmacology, Neurological Diseases

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 4  |  Issue : 3  |  Page : 158--169

Scopolamine induced behavioral and biochemical modifications and protective effect of Celastrus paniculatous and Angelica glauca in rats


Atul Puri1, Pranay Srivastava2, Preeti Pandey3, Rajesh Singh Yadav4, Prakash Chandra Bhatt5 
1 Department of Pharmacology, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela, Odisha, India
2 Department of Pharmacology and Toxicology, College of Pharmacy, KLE University, Belgaum, Karnataka, India
3 Department of Pharmaceutical Sciences, Kumaon University, Nainital, Uttarakhand, India
4 Department of Criminology and Forensic Science, School of Applied Sciences, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh, India
5 Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Centre for Advances Research in Pharmaceutical Sciences, New Delhi, India

Correspondence Address:
Prakash Chandra Bhatt
Faculty of Pharmacy, Centre for Advances Research in Pharmaceutical Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi
India

Introduction: Nootropic agents, including cholinesterase inhibitors are being used to improve memory, mood and behavior, but the side-effects associated with these agents have made their use limited. The present study has therefore been undertaken to assess the synergistic effects of Celastrus paniculatous and Angelica glauca on scopolamine induced dementia in rats. Materials and Methods: Rats were treated with scopolamine (1 mg/kg body weight, i.p.) alone and with donepezil (2 mg/kg body weight p.o.), C. paniculatous (150 mg/kg body weight, p.o) and A. glauca (150 mg/kg body weight, p.o.). The changes in behavioral and biochemical parameters were assessed in rats. Results: Scopolamine treated rats showed impaired learning and memory, increased activity of acetylcholinesterase (AChE) (18%), lipid peroxidation (60%), protein carbonyls (47%) and decreased levels of reduced glutathione (GSH) (35%), activity of superoxide dismutase (34%) and catalase (42%) in hippocampus as compared with control. Simultaneous treatment of C. paniculatous and A. glauca with scopolamine also caused an improvement in the learning and memory activity associated with AChE activity in hippocampus of rats as compared to those treated with scopolamine alone. Combined treatment of C. paniculatous, A. glauca and scopolamine significantly improved the learning and memory function and AChE activity (30%) associated with decreased lipid peroxidation (33%), protein carbonyls (27%) and increased levels of antioxidant enzymes like reduced GSH (46%), activity of superoxide dismutase (50%) and catalase (62%) in hippocampus of rats as compared with those treated with scopolamine alone. Conclusion: The results of the present study exhibit protective efficacy of combined treatment of C. paniculatous and A. glauca in scopolamine induced dementiaand promising as a memory enhancing agents that is associated with its strong antioxidant potential.


How to cite this article:
Puri A, Srivastava P, Pandey P, Yadav RS, Bhatt PC. Scopolamine induced behavioral and biochemical modifications and protective effect of Celastrus paniculatous and Angelica glauca in rats.Int J Nutr Pharmacol Neurol Dis 2014;4:158-169


How to cite this URL:
Puri A, Srivastava P, Pandey P, Yadav RS, Bhatt PC. Scopolamine induced behavioral and biochemical modifications and protective effect of Celastrus paniculatous and Angelica glauca in rats. Int J Nutr Pharmacol Neurol Dis [serial online] 2014 [cited 2019 Sep 21 ];4:158-169
Available from: http://www.ijnpnd.com/article.asp?issn=2231-0738;year=2014;volume=4;issue=3;spage=158;epage=169;aulast=Puri;type=0