International Journal of Nutrition, Pharmacology, Neurological Diseases

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 3  |  Issue : 3  |  Page : 294--302

Antioxidant and anti-inflammatory potential of hesperidin against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced experimental Parkinson«SQ»s disease in mice


Kuppusamy Tamilselvam1, Jagadhesan Nataraj1, Udaiyappan Janakiraman1, Thamilarasan Manivasagam1, Mustafa Mohammed Essa2 
1 Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India
2 Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman

Correspondence Address:
Thamilarasan Manivasagam
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, Tamil Nadu
India

Background : There is mounting evidence that flavonoid consumption is potentially beneficial to those suffering from neurodegenerative diseases, cardiovascular disease, and cancer. These beneficial properties are largely attributed to their medicinal values. Objectives: In this study, we evaluated the neuro-protective effect of black hesperidin against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced behavioral deficits, oxidative stress, and inflammation. Results: Behavioral analyses showed that hesperidin ameliorates MPTP-induced motor dysfunction. Elevated level of thiobarbituric acid reactive substances and enhanced activities of superoxide dismutase and catalase with deprived levels of reduced glutathione and activities of glutathione peroxidase in MPTP group was attenuated significantly in hesperidin-treated group. Administration of MPTP-induced glial activation observed by primary marker Glial Fibrillary Acidic Protein increased the release of pro-oxidant Cyclooxygenase - 2 and inflammatory cytokines such as Interleukin-1β, Tumor necrosis factor-α, IL-6, IL-4, and IL-10 in striatum and substania nigra. Treatment of hesperidin significantly protects microglia activation and reduces the release of inflammatory cytokines proving the anti-inflammatory effect of hesperidin. Conclusion: These findings suggest that hesperidin partially attenuates MPTP-induced neurotoxicity through its antioxidant and anti-inflammatory properties.


How to cite this article:
Tamilselvam K, Nataraj J, Janakiraman U, Manivasagam T, Essa MM. Antioxidant and anti-inflammatory potential of hesperidin against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced experimental Parkinson's disease in mice.Int J Nutr Pharmacol Neurol Dis 2013;3:294-302


How to cite this URL:
Tamilselvam K, Nataraj J, Janakiraman U, Manivasagam T, Essa MM. Antioxidant and anti-inflammatory potential of hesperidin against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced experimental Parkinson's disease in mice. Int J Nutr Pharmacol Neurol Dis [serial online] 2013 [cited 2020 Feb 17 ];3:294-302
Available from: http://www.ijnpnd.com/article.asp?issn=2231-0738;year=2013;volume=3;issue=3;spage=294;epage=302;aulast=Tamilselvam;type=0