International Journal of Nutrition, Pharmacology, Neurological Diseases

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 1  |  Issue : 2  |  Page : 146--151

Tephrosia purpureaLinn leaves attenuate pain and inflammation in experimental animals


Vishal Gulecha1, Thangavel Sivakumar3, Aman Upaganlawar2, Rakesh Khandare2, Chandrashekhar Upasani2 
1 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik; Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamil Nadu, India
2 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik, India

Correspondence Address:
Vishal Gulecha
Department of Pharmacology, SNJBSQS SSDJ College of Pharmacy Neminagar, Chandwad, Nashik
India

Aim : Present study evaluates the analgesic and anti-inflammatory activities of different fractions of Tephrosia purpurea using various experimental models. Materials and Methods: The analgesic activity of T. purpurea carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-granuloma formation in rats. The effects of the administration of reference standard (Ibuprofen and hydrocortisone) were also evaluated. Results: Five different fractions (TPI, TPII, TPIII, TPIV, and TPV) of T. purpurea at the dose level of 20 and 40 mg/kg, p.o. were tested. The fraction TPI (40 mg/kg, p.o.) and TPIII (40 mg/kg, p.o.) were found to be more effective in preventing carrageenan induced rat paw edema, cotton pellet granuloma formation and acetic acid-induced writhing; however, TPI (20 mg/kg, p.o.) and TPIII (20 mg/kg, p.o.) were found to be more effective in increasing latency period in tail flick method. Conclusions: Out of five different fractions of T. purpurea tested, TPI and TPIII possess potent analgesic and anti-inflammatory activities against different models of inflammation and pain.


How to cite this article:
Gulecha V, Sivakumar T, Upaganlawar A, Khandare R, Upasani C. Tephrosia purpureaLinn leaves attenuate pain and inflammation in experimental animals.Int J Nutr Pharmacol Neurol Dis 2011;1:146-151


How to cite this URL:
Gulecha V, Sivakumar T, Upaganlawar A, Khandare R, Upasani C. Tephrosia purpureaLinn leaves attenuate pain and inflammation in experimental animals. Int J Nutr Pharmacol Neurol Dis [serial online] 2011 [cited 2020 Feb 17 ];1:146-151
Available from: http://www.ijnpnd.com/article.asp?issn=2231-0738;year=2011;volume=1;issue=2;spage=146;epage=151;aulast=Gulecha;type=0