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ORIGINAL ARTICLE
Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 59-65

Neuroprotective Effect of Agaricus Blazei Extract Against Rotenone-Induced Motor and Nonmotor Symptoms in Experimental Model of Parkinson’s Disease


1 Department of Anatomy, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
2 Department of Anatomy, Velammal Medical College, Madurai, Tamil Nadu, India
3 Department of Anatomy, Sree Balaji Medical College, Chennai, Tamil Nadu, India

Correspondence Address:
Srinavasagam Rajasankar
Department of Anatomy, Velammal Medical College, Madurai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnpnd.ijnpnd_20_18

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Introduction: In our earlier studies, we reported that rotenone-induced mitochondrial dysfunction, oxidative stress, and apoptosis in the brain of mice have been protected through treatment with Agaricus blazei (A. blazei) extract. The present study is focused on the efficacy of A. blazei in the mitigation of motor and nonmotor symptoms induced by rotenone. Materials and Methods: Mice were randomly divided into four groups and treated with rotenone and simultaneously with A. blazei. Results: Rotenone treatment altered both the motor and nonmotor behavioral deficits as compared to controls. Concurrent treatment with rotenone and A. blazei significantly restored these behavioral deficits. Conclusion: The results of the present study strengthen the fact that the nutritional supplement of A. blazei extract in rotenone-affected areas might offer the neuroprotection.


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