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ORIGINAL ARTICLE
Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 35-40

Attenuation of Aluminum-Induced Neurotoxicity by Tannoid Principles of Emblica officinalis in Wistar Rats


Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India

Correspondence Address:
Arokiasamy Justin Thenmozhi
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnpnd.ijnpnd_23_18

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Introduction: In our earlier studies, we reported the neuroprotective effect of tannoid principles of Emblica officinalis (EoT) against aluminum chloride (AlCl3)-induced neurotoxicity in the hippocampus and cortex of rats. The present study is focused on the efficacy of EoT in the mitigation of AlCl3-induced toxicity in the cerebellum. Materials and Methods: Rats were randomly divided into four groups and treated with AlCl3 (100 mg/kg, b.w. i.p.), EoT (100 mg/kg, b.w. oral), and simultaneously with AlCl3 and EoT daily for 60 days. Results: AlCl3 treatment altered the body weight, brain and cerebellum weight, Al levels, acetylcholinesterase activity, and the expression of apoptotic markers. Treatment with EoT attenuated these physiological, biochemical, and molecular indices. Conclusion: The results of the present study strengthen the fact that the nutritional supplement of EoT in AlCl3-treated rats might improve the adverse effects by its pharmacological properties.


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