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ORIGINAL ARTICLE
Year : 2018  |  Volume : 8  |  Issue : 1  |  Page : 10-15

The Potency of Nanoparticle of Pinus merkusii as Immunostimulatory on Male Wistar Albino Rat


1 Department of Pharmacology, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia
2 Department of Pharmacy Biology, Faculty of Pharmacy, Hang Tuah University, Surabaya, Indonesia
3 Department of Conservative Dentistry, Faculty of Dentistry, Airlangga University, Surabaya, Indonesia
4 Study Program of Environmental Health, Polytechnic of Health, Surabaya, Indonesia

Correspondence Address:
Sri Agus Sudjarwo
Department of Pharmacology, Faculty of Veterinary Medicine, Airlangga University, Surabaya - 60115
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnpnd.ijnpnd_72_17

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Objective: Medicinal herbs are the commonly used worldwide immunomodulators in the management of various disease conditions. The aim of this study was to evaluate the immunostimulatory activity of the nanoparticle extract of Pinus merkusii in Wistar albino rats. Materials and Methods: It was an experimental study that was conducted on various groups of animals each with six healthy adult rats. Neutrophil adhesion test, hemagglutinating antibody (HA) titer, delayed-type hypersensitivity (DTH) response, phagocytic activity, and cyclophosphamide-induced myelosuppression were determined in various groups of animals. Results: The nanoparticle of extract P. merkusii at doses 500 mg/kg BW but not at doses 125 mg/kg BW and 250 mg/kg BW induced a significant increase in percent neutrophil adhesion fibers as well as a dose-dependent increase in antibody titer values and potentiated the DTH reaction induced by sheep red blood cells. Also, it prevented myelosuppression in cyclophosphamide drug-treated rats and good response toward phagocytosis in carbon clearance assay. Conclusion: From these findings, it can be concluded that nanoparticle extract of P. merkusii possesses immunostimulatory activity and has therapeutic potential for the prevention of immune-depressed conditions.


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