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ORIGINAL ARTICLE
Year : 2016  |  Volume : 6  |  Issue : 2  |  Page : 76-80

Survival outcomes of buccal mucosa carcinoma patients with multimodal therapy: An institutional study


1 Department of Medical Research, SRM Medical College Hospital and Research Centre, SRM University, Kanchipuram, Tamil Nadu, India
2 Department of Public Health, SRM Medical College Hospital and Research Centre, SRM University, Kanchipuram, Tamil Nadu, India

Correspondence Address:
Sivapatham Sundaresan
Department of Medical Research, SRM Medical College Hospital and Research Centre, SRM University, Kattankulathur, Kanchipuram, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.179967

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Background/Objectives: The buccal mucosa carcinoma is the most common site for oral squamous cell carcinoma. Treatment of oral squamous cell carcinoma has classical method of surgical resection and post-operative adjuvant chemo and radiotherapy. Despite, this multimodality treatment five year survival remains poor. Therefore, this study had been conducted to assess survival outcome of buccal mucosa carcinoma by different treatment strategies. Materials and Methods: Demographic, pathologic, treatment and survival data was retrieved from hospital registries from 2013-2015 in Arignar Anna Memorial Cancer Hospital and Research Centre, Kanchipuram. Actuarial overall and relapse-free survivals were estimated with Kaplan-Meier method. Results and Discussion: A total of 198 buccal mucosa carcinoma subjects comprised 125(63.1%) male and 73(36.9%) female in 1.7:1 ratio. Type of treatment had significant association of subjects age, cellular differentiation, clinical stage of disease and regional lymph nodes by chi-square analysis (P < 0.05). Three years estimated overall survival and time to recurrence (TTR) was 96.46% and 3.54% respectively. Subjects receiving multimodality treatment (post operative radiotherapy and with adjuvant chemotherapy) improved overall and time to recurrence (TTR) compared to radio and chemo radiotherapy alone (P < 0.05). Conclusion: This study shows that adding adjuvant chemotherapy with post operative radiotherapy improves better survival outcomes.


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