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ORIGINAL ARTICLE
Year : 2015  |  Volume : 5  |  Issue : 2  |  Page : 50-55

Evaluation of the wound-healing potential of Amaranthus viridis (Linn.) in experimentally induced diabetic rats


1 Department of Pharmacology and Experimental Biology, Vedica College of Pharmacy, Ram Krishna Dharmarth Foundation (RKDF) University, Bhopal, Madhya Pradesh, India
2 Department of Pharmaceutical Chemistry, Sri Sivani College of Pharmacy, Srikakulam, Andhra Pradesh, India
3 Department of Analytical Chemistry, Sri Sivani College of Pharmacy, Srikakulam, Andhra Pradesh, India

Correspondence Address:
Himanshu Bhusan Sahoo
Department of Pharmacology and Experimental Biology, Vedica College of Pharmacy, Ram Krishna Dharmarth Foundation (RKDF) University, Bhopal, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.153792

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Objective: This study aimed to evaluate the wound-healing potential of the ethanolic extract of Amaranthus (A.) viridis leaves in diabetic rats. Materials and Methods: Diabetes was induced by the administration of a single injection of alloxan monohydrate (120 mg/kg, i.p.) prepared in citrate buffer to experimental animals. The wound-healing activity was evaluated by three methods: excision, incision, and dead space wound models. The diabetic animals were divided into five groups, as follows: Group I, which received alloxan treatment only (diabetic control); Group II, which received topical mupirocin ointment (2% w/w) (standard); Groups III, IV, and V, which were treated with ointments prepared from A. viridis extract of 2%, 5%, and 10% w/w, respectively, daily (test groups) till the wounds completely healed. Wound-healing parameters such as the rate of wound contraction, epithelization, tensile strength, and concentration of hydroxyproline content were measured and compared with diabetic control using one-way analysis of variance (ANOVA) followed by Dunnett's test. Results: Rats treated with the prepared ointments of A. viridis extract had shown a significant (P < 0.01) increase in the percentage of wound closure, tensile strength, and hydroxyproline content of the granulation tissue when compared with the diabetic control, in a dose-dependent pattern. Conclusion: These findings demonstrated that the ointments of A. viridis leaf extract effectively stimulate wound contraction and accelerate wound healing in diabetic rats.


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