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ORIGINAL ARTICLE
Year : 2015  |  Volume : 5  |  Issue : 1  |  Page : 20-27

Chrysin enhances antioxidants and oxidative stress in L-NAME-induced hypertensive rats


1 Department of Biochemistry, Rajah Serfoji Government College, Thanjavur, Tamil Nadu, India
2 Department of Zoology, Nizam College, Hyderabad, Telangana, India

Correspondence Address:
Rajagopal Senthilkumar
Department of Zoology, Nizam College, Hyderabad - 500 001, Telangana
India
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Source of Support: This work was supported by Department of Biotechnology, Ministry of Science and Technology, Govt. of India to R.S. The content is solely the responsibility of the authors and doesn’t necessarily represent the views of the Department of Biotechnology, Govt. of India., Conflict of Interest: None


DOI: 10.4103/2231-0738.150069

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Objectives: The study seeks to evaluate the effect of chrysin; a natural, biologically active compound extracted from plants, honey or propolis, on the tissues and circulatory antioxidant status and lipid peroxidation in Nω-nitro-l-arginine methyl ester (L-NAME) induced hypertensive rats. Materials and Methods: Male albino rats were divided into four groups. Control (Group I) and chrysin supplementation of the control (Group II) received normal diet. Groups III and IV received L-NAME (40 mg/kg B.W). Groups II and IV received chrysin (25 mg/kg B.W) dissolved in 0.2% dimethylsulfoxide solution after the 4 th week. Results and Discussion: The results showed significantly elevated levels of tissue and circulatory thiobarbituric acid reactive substances, conjugated dienes and lipid hydroperoxides, and significantly lowered enzymic and non-enzymic antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, vitamin C and vitamin E in L-NAME-induced hypertensive rats compared with those in control group. From chrysin administration to rats with L-NAME-induced hypertension leads to tissue damage which significantly decreases the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes, and significantly elevates the activity of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, vitamin C and vitamin E in the tissues and circulation compared with those on the unsupplemented L-NAME induced hypertensive group. Conclusions: Chrysin offers protection against free radical-mediated oxidative stress in rats with L-NAME-induced hypertension.


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