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ORIGINAL ARTICLE
Year : 2015  |  Volume : 5  |  Issue : 1  |  Page : 13-19

Screening of novel polyphyto formulations, a natural remedies for learning and memory enhancing properties in rat


1 Department of Pharmacology and Pharmacy Practice, Research Scholar, Uttarakhand Technical University, Uttarakhand, India
2 Department of Pharmacy, Dehradun Institute of Technology University, Faculty of Pharmacy, Dehradun, Uttarakhand, India
3 Department of Nephrology, Fortis Hospital, Anandpur, Kolkata, West Bengal, India

Correspondence Address:
Shibnath Kamila
Department of Pharmacy Practice, Bharat Institute of Technology, Ibrahimpatnam, Mangalpally, Ranga Reddy - 500 010, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.150067

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Aim: The present study objective is to find out the effectiveness of the two medhya (polyphyto) formulations for its learning and memory activity. Materials and Methods: There is a hypothesis is to slow down the brain degeneration caused by different pathophysiology with natural treatments and it has shown the promising effect in the treatment of memory loss. The two medhya formulation test drugs are FM01 (Habiscus rosasinensis, Oscimum sanctum, Santalum album, Phyllanthus Emblica, Convolulus pluricaulis, Bacopa monnieri), and FM02 (Convolulus pluricaulis, Abelmoschus esculentus, Terminalia Arjuna, Phyllanthus Emblica, Avena sativa) at a dose of (50 mg and 100 mg/kg p.o.) studied against standard drug Bacopa monnieri having potential effect to improving memory, evaluate it using three different animal model like Elevated plus maze (EPM), Morris water maze (MWM) and Pole Climbing apparatus (PCA) for the effect of nootropic action. Results: On administration of polyphyto formulations FM01 and FM02 showed significant (P < 0.001) reduction in transfer latency in EPM, MWM and escape latency in PCA test as compared with the control; whereas FM01 is comparatively better than FM02 and Bacopa monnieri. Conclusion: It was concluded that the nootropic polyphyto FM01 formulation composed of (Habiscus rosasinensis 30%, Oscimum sanctum 20%, Santalum album 15%, Phyllanthus Emblica 15%, Convolulus pluricaulis 10%, Bacopa monnieri 10%) having promising significant effect for enhancing learning and memory properties can be use for memory loss or dementia and prophylactically can be use to prevent neurodegeneration.


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