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ORIGINAL ARTICLE
Year : 2014  |  Volume : 4  |  Issue : 4  |  Page : 231-236

Adaptogenic and nootropic activity of Mimosa pudica in albino wistar rats


1 Department of Pharmacology, Neuropharmacology Research Division, Mahatma Gandhi University, Kottayam, Kerala, India
2 Research Scholar, University College of Pharmacy, Cheruvandoor Campus, Mahatma Gandhi University, Kottayam, Kerala, India

Correspondence Address:
Sibi Perumbamkudiyil Ittiyavirah
Department of Pharmacology, Neuropharmacology Research Division, University College of Pharmacy, Cheruvandoor Campus, Mahatma Gandhi University, Kottayam 686 631, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.139404

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Aim: To evaluate the adoptogenic activity of ethanolic extract of Mimosa pudica L. in chronic Alzheimer's model. Materials and Methods: The dried whole part of the plant were subjected to hot continuous extraction method using ethanol as solvent and were standardized using pharmacognostical and phytochemical screening. The in-vitro antioxidant studies were conducted by super oxide scavenging assay and hydrogen peroxide scavenging assay. Satisfactory IC 50 values were obtained for both assays. Dose selection for in-vivo study was made on the basis of already conducted acute toxicity studies (500 mg/kg body weight). Oral administration of extract of M. pudica was continued for 21 consecutive days. Adaptogenic activity was assessed by using oral dose of 500 mg/kg of EEMP and 2 mg/kg diazepam as test and standard compound respectively. Results: There was a significant improvement in memory, which was observed from the test paradigms viz., morris water maze, radial arm maze. Forced swim test was used as the observation paradigm for the adaptogenic activity and EEMP caused significant reduction in swimming endurance time. Conclusion: It was concluded that ethanolic extract of M. pudica at the dose of 500 mg/kg p.o produces potential changes in chronic Alzheimer's model and stress.


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