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ORIGINAL ARTICLE
Year : 2014  |  Volume : 4  |  Issue : 3  |  Page : 170-178

Preparation and screening of Swarnaprashana for nootropic activity


1 Department of Pharmacognosy, Soniya Education Trust's College of Pharmacy, Mangalore, Karnataka, India
2 Doctor of Ayurveda, Sankalpa Clinic, Dharwad, Shree Devi College of Pharmacy, Mangalore, Karnataka, India
3 Department of Pharmacology, Soniya Education Trust's College of Pharmacy, Mangalore, Karnataka, India
4 Department of Pharmacology, Shree Devi College of Pharmacy, Mangalore, Karnataka, India

Correspondence Address:
Vijayanand Basabaraj Warad
Post Graduate, Department of Pharmacognosy, Soniya Education Trust's College of Pharmacy, S. R. Nagar, Dharwad 580 002, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.132677

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Context: Cognitive disorders are responsible for memory impairments, deterioration of language, motor, sensory abnormalities, gait disturbance, and seizures. Nootropic agents are being primarily used to improve memory, mood and behavior. Aims: In the present study, it was aimed to prepare and evaluate the traditional formulation, Swarnaprashana for its nootropic efficacy on the learning and memory by employing exteroceptive and interoceptive behavioral models in young and aged mice. Settings and Design: In the present study, Swarnaprashana (30 mg/kg, p.o.) was administered to young and aged Swiss albino mice for 15 days. The elevated plus-maze and Morris water maze were used as exteroceptive behavior models. Materials and Methods: Swarnaprashana was prepared by mixing Swarnabhasma (gold) with honey and ghee was used as vehicle. Scopolamine and naturally ageing-induced amnesic models were used as interoceptive behavior models. Biochemical parameter such as whole brain acetylcholinesterase (AChE) activity is used to quantify the nootropic activity. Piracetam (200 mg/kg, p.o.) was used as a standard nootropic agent. Statistical Analysis Used: All data were expressed as mean ± standard error of the mean of 6 mice/experimental group. Parametric one-way analysis of variance followed by Tukey's posttest. Statistical analyses were performed using Graph pad prism 5.0. The minimal level of significance was identified at P < 0.05. Results: The pretreatment of Swarnaprashana (30 mg/kg, p.o.) exhibited significant improvement in learning and memory (P < 0.01) and also showed significant (P < 0.001) decrease in whole brain AChE activity. Conclusions: The present findings suggest that formulation Swaranaprashana has nootropic and anti-AChE activity. Hence, it can be employed in enhancing the memory of the child and for the treatment and management of Alzheimer's disease.


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