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ORIGINAL ARTICLE
Year : 2014  |  Volume : 4  |  Issue : 2  |  Page : 118-124

Antidepressant activity of aqueous extract of Phaseolus vulgaris (black bean) in rodent models of dep ression


Department of Pharmacology, Rayat Institute of Pharmacy, Railmajra, Shahid Bhagat Singh Nagar, Punjab, India

Correspondence Address:
Madhu Devi
Department of Pharmacology, Rayat Institute of Pharmacy, Railmajra, Shahid Bhagat Singh Nagar - 144 533, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.129603

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The aim of this study was to investigate the potential antidepressive effect of aqueous extract of Phaseolus vulgaris (AEPV) and its mechanism of the antidepressant-like action in validated models of depression. Force swim test (FST) in rats and 5-hydroxytryptophan (5-HTP)-induced head-twitch responses (HTRs) in mice were performed to assess the potential antidepressant-like activity of AEPV. Oral administration of AEPV markedly reduced the duration of immobility during the FST in dose-dependent (250 and 500 mg/kg) manner and these effects were similar to that of imipramine. However, AEPV at a dose of 500 mg/kg, p.o. potentiate 5-HTP-induced HTR in mice, as similar to that of fluoxetine (FLU). In conclusion, this study depicts the antidepressant-like effect of AEPV in animal models of depression.


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