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ORIGINAL ARTICLE
Year : 2014  |  Volume : 4  |  Issue : 1  |  Page : 69-73

Association between serum cholesterol, brain serotonin, and anxiety: A study in simvastatin administered experimental animals


1 Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Medical College, Trivandrum, Kerala, India
2 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, India

Correspondence Address:
Jaya Mary Thomas
Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Medical College, Trivandrum, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.124617

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Introduction: The present research was designed to investigate the association between serum cholesterol, brain serotonin, and anxiety in simvastatin administered experimental animals. Materials and Methods: Both mice and rats were used for the study. Simvastatin (50 and 100 mg/kg in rats and 70 and 140 mg/kg in mice) was administered orally for one month. Serum cholesterol and brain serotonin levels were monitored. Two behavioral models, elevated plus maze test and mirrored chamber test were used to evaluate anxiety in the animals. Results: Simvastatin caused a significant reduction (P < 0.01) in serum cholesterol and brain serotonin level compared with the control group of animals. Animals treated with simvastatin showed significant level of anxiety in the behavioral models when compared with the control group. Conclusion: Hence these experimental results have established the pharmacological evidence to the hypothesis for the relation between serum cholesterol, brain serotonin, and symptoms of anxiety and also confirm that long-term administration of lipophilic statins can lead to anxiety.


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