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ORIGINAL ARTICLE
Year : 2014  |  Volume : 4  |  Issue : 1  |  Page : 64-68

A new weapon for memory power: Elephantopus scaber (Linn.)


1 Department of Pharmacology and Experimental Biology, Vedica College of Pharmacy, Ram Krishna Dharmarth Foundation University, Bhopal, India
2 Department of Pharmacology, Veer Surendra Sai Medical College, Burla, Odisha, India
3 Department of Pharmaceutical Science, Asia Metropolitan University, Cheras, Selangor, Malaysia
4 Department of Pharmacognosy and Phytochemistry, Vedica College of Pharmacy, Ram Krishna Dharmarth Foundation University, Bhopal, Madhya Pradesh, India

Correspondence Address:
Amrita Bhaiji
Department of Pharmacognosy and Phytochemistry, Vedica College of Pharmacy, Ram Krishna Dharmarth Foundation University, Bhopal - 462 033, Madhya Pradesh
India
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Source of Support: Vedica College of Pharmacy, RKDF University, Bhopal, Madhyapradesh, India., Conflict of Interest: None


DOI: 10.4103/2231-0738.124616

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Aims: To investigate the memory enhancing potential of ethanolic extract of Elephantopus scaber (Linn.) leaves (EESL) in Swiss albino aged mice along with its possible mode of action. Materials and Methods: The memory enhancing activity was estimated by measurement of transfer latency (TL) in elevated plus maze test; step-down latency (SDL) in passive avoidance test, cholinesterase and caspase level from brain homogenate of mice. The EESL at the dose of 150, 300, and 600 mg/kg of body weight was administered orally for 15 days to different groups (n = 6) of aged mice and was found dose dependent improvement in memory score after termination period. Results: In aged mice, EESL reversed significantly amnesiatic potential in TL and SDL, reduced significantly cholinesterase level, and increased significantly caspase level as compared to control group. Conclusions: These above finding suggest that the EESL may exhibit memory enhancing activity in aged mice and this enhancement of memory may be due to increase anticholinesterase and caspase activity in mice brain.


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