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ORIGINAL ARTICLE
Year : 2014  |  Volume : 4  |  Issue : 1  |  Page : 58-63

Role of chrysin on hepatic and renal activities of Nω-nitro-l-arginine-methylester induced hypertensive rats


Department of Biochemistry, Rajah Serfoji Government College, Thanjavur, Tamil Nadu, India

Correspondence Address:
Malarvili Thekkumalai
Department of Biochemistry, Rajah Serfoji Government College, Thanjavur - 613 001, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.124615

Clinical trial registration ijnpnd_75_13

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Objectives: The present study was undertaken to assess the antihypertensive, anti-hepatic and anti-renal activity of chrysin on Nω-nitro-l-arginine methyl ester (l-NAME) induced hypertensive rats. Materials and Methods: Hypertension was induced in adult male albino rats of the Wistar strain, weighing 180-220 g, by oral administration of the l-NAME (40 mg/kg B.W/day) in drinking water for 4 weeks. Rats were treated with chrysin (25 mg/kg B.W/day) for 4 weeks. Results and Discussion: Hypertension was manifested by considerably increased systolic and diastolic blood pressure and the toxic effect of 1-NAME was determined using the hepatic markers of lactate dehydrogenase, gamma glutamyl transpeptidase, renal markers of serum creatinine, creatinine clearance, urea, uric acid levels, urinary arachidonic acid metabolites of 6-keto-prostaglandin F 1α, thromboxane B2, 8-isoprostane-prostaglandin F and inflammatory parameters interleukin-6, tumor necrosis factor-alpha. Supplementation of chrysin at the dosage of 25 mg/kg considerably decreased systolic and diastolic blood pressure, hepatic markers, renal markers, urinary arachidonic acid metabolites and inflammatory parameters. Conclusion: These results suggest that chrysin decreases the blood pressure, significantly restores hepatic marker, renal markers, urinary arachidonic acid metabolites and inflammatory parameters and thus exhibits antihypertensive and anti-renal effects in l-NAME induced hypertensive rats.


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