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REVIEW ARTICLE
Year : 2014  |  Volume : 4  |  Issue : 1  |  Page : 28-42

Neuropathology staging and treatment strategies of Alzheimer's disease: An update


Department of Pharmacology, School of Phamracy,Babu Banarasi Das University, Babu Banarasi Das City, Faizabad Road, Chinhat, Lucknow, Uttar Pradesh, India

Correspondence Address:
Ashutosh Kumar Yadav
Department of Pharmacology, School of Phamracy, Babu Banarasi Das University, Babu Banarasi Das City, Faizabad Road, Chinhat, Lucknow - 227 105, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.124612

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Alzheimer's disease (AD) is a devastating neurodegenerative disorder manifested by deterioration in memory and cognition, impairment in performing activities of daily living. The pathological hallmark of AD is widespread neuritic plaques which are accumulation of amyloid beta protein and neurofibrillary tangles. This review has been done on various causes due to neurofibrillary tangles, senile plaque, gene, and different factors involved in aging and injury. Treatment of AD targeting toward cholinergic deficiency, oxidative stress, protein oxidation, protein nitration, tau and tangles formation, mitochondrial dysfunction, and inflammation. Pharmaceutical therapies include cholinesterase inhibitors, memantine, antihypertensive drugs, anti-inflammatory drugs, secretase inhibitors, brain-derived neurotrophic factor, and immunization. Nutrition and natural therapies, various vitamins and minerals also play a role in treatment. Approaches that target several dysfunctions simultaneously and that emphasize nutritional, natural, and stimulatory therapies may offer the most benefit at this time.


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