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ORIGINAL ARTICLE
Year : 2013  |  Volume : 3  |  Issue : 3  |  Page : 303-308

Anti-inflammatory and analgesic activities of Dashanga Ghana: An Ayurvedic compound formulation


1 Department of Rasa Shastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
2 Drug Discovery Laboratory, Himalaya Health Care, Makali, Bangalore, India
3 R & D Unit, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India

Correspondence Address:
Galib Ruknuddin
Department of Rasa shastra and Bhaishajya kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.114877

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Background and Objectives : Inflammation is the self-protective reaction of tissues towards infection, irritants, or foreign substances. Though it is a part of host defence mechanism, when it becomes severe, it turns out to be a hopeless condition which causes damage of tissues; hence control of inflammation becomes essential. In Ayurvedic texts, a number of medicinal preparations to combat inflammation have been found; among them, Dashanga Yoga is one, which is said to be significant in combating inflammation. To revalidate this claim, the present experimental study was undertaken. Materials and Methods : Wistar strain albino rats weighing 200 ± 20 g and Swiss albino mice (26 ± 2 g) of either sex were used in the study. Pharmacologically validated models were used to evaluate anti-inflammatory and analgesic effects. Dashanga Yoga was administered at dose of 45 mg/kg and 65 mg/kg for rat and mouse, respectively. Results : Dashanga Yoga significantly inhibited carrageenan-induced paw edema (P < 0.01) at both three and six hours; however, it failed to suppress formalin-induced paw edema. It decreased the formation of granulation tissue non-significantly in the chronic inflamatory model. In analgesic activity, pretreatment with Dashanga Yoga failed to inhibit the early phase of pain, whereas moderate inhibition occurred in the late phase of pain in the formalin-induced paw-licking model. In the tail fl ick model, Dashanga Yoga significantly increased tail flick latency at 120, 180, and 240 minutes in comparison to the control group. Conclusion : The results revealed that Dashanga Yoga has anti-inflammatory and analgesic activity. Hence, it can be used in the management of pain and inflammatory conditions.


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