Users Online: 831

Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 
     
ORIGINAL ARTICLE
Year : 2013  |  Volume : 3  |  Issue : 3  |  Page : 294-302

Antioxidant and anti-inflammatory potential of hesperidin against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced experimental Parkinson's disease in mice


1 Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India
2 Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman

Correspondence Address:
Thamilarasan Manivasagam
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.114875

Rights and Permissions

Background : There is mounting evidence that flavonoid consumption is potentially beneficial to those suffering from neurodegenerative diseases, cardiovascular disease, and cancer. These beneficial properties are largely attributed to their medicinal values. Objectives: In this study, we evaluated the neuro-protective effect of black hesperidin against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced behavioral deficits, oxidative stress, and inflammation. Results: Behavioral analyses showed that hesperidin ameliorates MPTP-induced motor dysfunction. Elevated level of thiobarbituric acid reactive substances and enhanced activities of superoxide dismutase and catalase with deprived levels of reduced glutathione and activities of glutathione peroxidase in MPTP group was attenuated significantly in hesperidin-treated group. Administration of MPTP-induced glial activation observed by primary marker Glial Fibrillary Acidic Protein increased the release of pro-oxidant Cyclooxygenase - 2 and inflammatory cytokines such as Interleukin-1β, Tumor necrosis factor-α, IL-6, IL-4, and IL-10 in striatum and substania nigra. Treatment of hesperidin significantly protects microglia activation and reduces the release of inflammatory cytokines proving the anti-inflammatory effect of hesperidin. Conclusion: These findings suggest that hesperidin partially attenuates MPTP-induced neurotoxicity through its antioxidant and anti-inflammatory properties.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3493    
    Printed112    
    Emailed1    
    PDF Downloaded252    
    Comments [Add]    
    Cited by others 10    

Recommend this journal