Users Online: 34

Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 
     
REVIEW ARTICLE
Year : 2013  |  Volume : 3  |  Issue : 3  |  Page : 206-218

Silibinin: A promising anti-neoplastic agent for the future? A critical reappraisal


1 Clinical Pharmacology, Dr. Naveen's Care and Cure Clinic, Chandigarh, India
2 Gynecology and obstetrics, Dr. Naveen's Care and Cure Clinic, Chandigarh, India
3 Department of Internal Medicine, PGIMER, Chandigarh, India
4 Dentistry Dr. Naveen's Care and Cure Clinic, Chandigarh, India

Correspondence Address:
Naveen Chhabra
W.S. 334, Basti Sheikh, Jalandhar, Punjab
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.114836

Rights and Permissions

Silibinin, a flavonolignan, is the major active component of the milk thistle plant (Silybummarianum). Silibinin have been used as medicinal herbs in the treatment of liver cirrhosis, chronic hepatitis, and gallbladder disorders. Numerous studies suggest that silibinin is a powerful antioxidant and has hepatoprotective properties and anti-neoplastic effects against various carcinoma cells. Silibinin had shown promising anti-neoplastic effects against skin, breast, lung, pancreatic, colon, cervical, prostate, bladder, and kidney carcinomas in various in vitro/in vivo and preclinical studies. Treatment claims also include lowering cholesterol levels, reducing insulin resistance, and anti-viral activity. Other reported uses of milk thistle in folk medicine include as a treatment for malarial fever, bronchitis, peritonitis, uterine congestion, varicose veins, and as a milk production stimulant for nursing mothers. The aim of the present article is to review and summarize the pharmacokinetics, physical properties, the mechanism of action, and the effectiveness and safety of silibininin various cancers/neoplasms.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5667    
    Printed134    
    Emailed4    
    PDF Downloaded412    
    Comments [Add]    
    Cited by others 8    

Recommend this journal