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ORIGINAL ARTICLE
Year : 2013  |  Volume : 3  |  Issue : 2  |  Page : 96-101

Evaluation of anxiolytic activity of vanillin in wistar albino rats


Department of Pharmacology, Kasturba Medical College, Manipal University, Mangalore, India

Correspondence Address:
Mukta N Chowta
Department of Pharmacology, Manipal University, KMC l, Attavar, Mangalore - 575 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.112828

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Background and Objectives: Vanillin is one of the primary chemical components of the extract of the vanilla bean. Vanillin has been claimed to possess various beneficial effects like anti-mutagenic, anti-nociceptive, anti-invasive and metastasis inhibiting potential by suppressing enzymatic activity of matrix metalloproteinase-9. However, literature research revealed no scientific data on its anxiolytic activity. Hence, this study was designed to evaluate the anxiolytic activity of vanillin in wistar albino rats. Materials and Methods: The rats were divided into five groups (n = 6). Vanillin administered at the dose of 10,100,200 mg/kg/day, orally was compared with the standard drug Diazepam (1.0 mg/kg/day, oral) fed for the latter 10 days. The two pharmacologically validated models, elevated plus maze and bright and dark arena were used. The data presented was analyzed using Kruskal Wallis followed by Mann-Whitney Test. P <0.05 was considered as statistically significant. Result: Vanillin significantly reduced the time spent in closed arm, increased the entries into open arm both in chronic and acute model of elevated plus maze (P < 0.05) in all three doses (10,100,200 mg/kg) used. Time spent in open arm, percentage ratio of open arm entries and number of rears in open arm also increased. Maximum effect was seen with 100 mg/kg. In bright and dark arena test there was an increase in number of entries, time spent and rears in bright chamber both in acute and chronic study at all doses (P < 0.05). Conclusion: The present study demonstrates the anxiolytic activity of vanillin in wistar albino rats.


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